Title | Acute Disruption of Bone Marrow B Lymphopoiesis and Apoptosis of Transitional and Marginal Zone B Cells in the Spleen following a Blood-Stage Plasmodium chabaudi Infection in Mice. |
Publication Type | Journal Article |
Year of Publication | 2011 |
Authors | Bockstal, V., N. Geurts, and S. Magez |
Journal | J Parasitol Res |
Volume | 2011 |
Pagination | 534697 |
Date Published | 2011 |
ISSN | 2090-0031 |
Abstract | B cells and antibodies are essential for the protective immune response against a blood-stage Plasmodium infection. Although extensive research has focused on memory as well as plasma B-cell responses during infection, little is known about how malaria affects B-cell development and splenic maturation into marginal zone B (MZB) and follicular B (FoB) cells. In this study, we show that acute Plasmodium chabaudi AS infection in C57Bl/6 mice causes severe disruption of B lymphopoiesis in the bone marrow, affecting in particular pro-, pre-, and immature B cells as well as the expression of the bone marrow B-cell retention chemokine CXCL12. In addition, elevated apoptosis of transitional T2 and marginal zone (MZ) B cells was observed during and subsequent to the control of the first wave of parasitemia. In contrast, Folllicular (Fo) B cells levels were retained in the spleen throughout the infection, suggesting that these are essential for parasite clearance and proper infection control. |
DOI | 10.1155/2011/534697 |
Alternate Journal | J Parasitol Res |
PubMed ID | 21687602 |
PubMed Central ID | PMC3112522 |
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