Current status of vaccination against African trypanosomiasis.

TitleCurrent status of vaccination against African trypanosomiasis.
Publication TypeJournal Article
Year of Publication2010
AuthorsMagez, S., G. Caljon, T. Tran, B. Stijlemans, and M. Radwanska
JournalParasitology
Volume137
Issue14
Pagination2017-27
Date Published2010 Dec
Type of Articleparasites
ISSN1469-8161
KeywordsAntigenic Variation, Host-Parasite Interactions, Humans, Immunologic Memory, Protozoan Vaccines, Trypanosoma, Trypanosomiasis, African, Variant Surface Glycoproteins, Trypanosoma
Abstract

Anti-trypanosomiasis vaccination still remains the best theoretical option in the fight against a disease that is continuously hovering between its wildlife reservoir and its reservoir in man and livestock. While antigenic variation of the parasite surface coat has been considered the major obstacle in the development of a functional vaccine, recent research into the biology of B cells has indicated that the problems might go further than that. This paper reviews past and current attempts to design both anti-trypanosome vaccines, as well as vaccines directed towards the inhibition of infection-associated pathology.

DOI10.1017/S0031182010000223
Alternate JournalParasitology
PubMed ID20441680