African trypanosomiasis and antibodies: implications for vaccination, therapy and diagnosis.

TitleAfrican trypanosomiasis and antibodies: implications for vaccination, therapy and diagnosis.
Publication TypeJournal Article
Year of Publication2009
AuthorsMagez, S., and M. Radwanska
JournalFuture Microbiol
Volume4
Issue8
Pagination1075-87
Date Published2009 Oct
Type of Articleparasites
ISSN1746-0921
KeywordsAnimals, Antibodies, Protozoan, Antigens, Protozoan, B-Lymphocytes, Cattle, Humans, Immunologic Memory, Mice, Nanotechnology, Nucleic Acid Amplification Techniques, Protozoan Vaccines, Trypanosoma brucei gambiense, Trypanosomiasis, African
Abstract

African trypanosomiasis causes devastating effects on human populations and livestock herds in large parts of sub-Saharan Africa. Control of the disease is hampered by the lack of any efficient vaccination results in a field setting, and the severe side effects of current drug therapies. In addition, with the exception of Trypanosoma brucei gambiense infections, the diagnosis of trypanosomiasis has to rely on microscopic analysis of blood samples, as other specific tools are nonexistent. However, new developments in biotechnology, which include loop-mediated isothermal amplification as an adaptation to conventional PCR, as well as the antibody engineering that has allowed the development of Nanobody technology, offer new perspectives in both the detection and treatment of trypanosomiasis. In addition, recent data on parasite-induced B-cell memory destruction offer new insights into mechanisms of vaccine failure, and should lead us towards new strategies to overcome trypanosome defenses operating against the host immune system.

DOI10.2217/fmb.09.65
Alternate JournalFuture Microbiol
PubMed ID19824795