Tsetse fly saliva accelerates the onset of Trypanosoma brucei infection in a mouse model associated with a reduced host inflammatory response.

TitleTsetse fly saliva accelerates the onset of Trypanosoma brucei infection in a mouse model associated with a reduced host inflammatory response.
Publication TypeJournal Article
Year of Publication2006
AuthorsCaljon, G., J. Van Den Abbeele, B. Stijlemans, M. Coosemans, P. De Baetselier, and S. Magez
JournalInfect Immun
Volume74
Issue11
Pagination6324-30
Date Published2006 Nov
Type of Articleparasites
ISSN0019-9567
KeywordsAnimals, Disease Models, Animal, Down-Regulation, Female, Inflammation, Insect Vectors, Mice, Mice, Knockout, Microbial Sensitivity Tests, Saliva, Trypanosoma brucei brucei, Trypanosomiasis, African, Tsetse Flies
Abstract

Tsetse flies (Glossina sp.) are the vectors that transmit African trypanosomes, protozoan parasites that cause human sleeping sickness and veterinary infections in the African continent. These blood-feeding dipteran insects deposit saliva at the feeding site that enables the blood-feeding process. Here we demonstrate that tsetse fly saliva also accelerates the onset of a Trypanosoma brucei infection. This effect was associated with a reduced inflammatory reaction at the site of infection initiation (reflected by a decrease of interleukin-6 [IL-6] and IL-12 mRNA) as well as lower serum concentrations of the trypanocidal cytokine tumor necrosis factor. Variant-specific surface glycoprotein-specific antibody isotypes immunoglobulin M (IgM) and IgG2a, implicated in trypanosome clearance, were not suppressed. We propose that tsetse fly saliva accelerates the onset of trypanosome infection by inhibiting local and systemic inflammatory responses involved in parasite control.

DOI10.1128/IAI.01046-06
Alternate JournalInfect. Immun.
PubMed ID16954393
PubMed Central IDPMC1695494