|Title||Functional convergence of invertebrate and vertebrate cytokine-like molecules based on a similar lectin-like activity.|
|Publication Type||Journal Article|
|Year of Publication||2004|
|Authors||Beschin, A., M. Bilej, S. Magez, R. Lucas, and P. De Baetselier|
|Journal||Prog Mol Subcell Biol|
|Keywords||Animals, Cytokines, Cytotoxins, Host-Parasite Interactions, Immunity, Innate, Invertebrates, Lectins, Oligochaeta, Tumor Necrosis Factor-alpha, Vertebrates|
It is generally accepted that the action of cytokines results from their binding to specific receptors. However, many cytokines possess lectin-like activity that may be essential for the expression of their full biological activities. This review focuses on the physiological relevance of the lectin-like activity of cytokines during the innate immune response in mammals, using TNF as an illustrative example. Moreover, we will show that TNF displays functional analogies with a defense molecule from the earthworm Eisenia foetida termed CCF. These analogies are not reflected by primary sequence homology between CCF and TNF but are particularly based on a similar lectin-like activity/domain. Hence, from a phylogenetic point of view, the lectin-like activity/domain of CCF and TNF may represent an essential recognition mechanism that has been functionally conserved during the innate immune response of invertebrates and vertebrates as a result of convergent evolution.
|Alternate Journal||Prog. Mol. Subcell. Biol.|