Selective pressure can influence the resistance of Trypanosoma congolense to normal human serum.

TitleSelective pressure can influence the resistance of Trypanosoma congolense to normal human serum.
Publication TypeJournal Article
Year of Publication2002
AuthorsVan Xong, H., P. De Baetselier, E. Pays, and S. Magez
JournalExp Parasitol
Volume102
Issue2
Pagination61-5
Date Published2002 Oct
ISSN0014-4894
KeywordsAnimals, Blood Physiological Phenomena, Female, Humans, Mice, Parasitemia, Phenotype, Serial Passage, Trypanosoma congolense, Trypanosomiasis, African
Abstract

Resistance and sensitivity to normal human serum (NHS) of Trypanosoma congolense, a parasite believed to cause disease in animals only, were investigated in vivo as well as in vitro. Our results indicate that like Trypanosoma brucei, T. congolense can be grouped into three different phenotypes according to its resistance to NHS. Some strains are completely resistant to NHS, like Trypanosoma brucei gambiense and the resistant form of Trypanosoma brucei rhodesiense. Other strains show a very low degree of resistance comparable to the sensitive form of T. b. rhodesiense, and some are completely sensitive to NHS. Continuous passaging in mice in the presence or absence of NHS shows that the resistance and sensitivity of T. congolense can be reversed like in T. b. rhodesiense. Our data suggest that T. congolense might be able to infect man in regions where animals may serve as reservoirs for the infection.

Alternate JournalExp. Parasitol.
PubMed ID12706740