VSG-GPI anchors of African trypanosomes: their role in macrophage activation and induction of infection-associated immunopathology.

TitleVSG-GPI anchors of African trypanosomes: their role in macrophage activation and induction of infection-associated immunopathology.
Publication TypeJournal Article
Year of Publication2002
AuthorsMagez, S., B. Stijlemans, T. Nath Baral, and P. De Baetselier
JournalMicrobes Infect
Volume4
Issue9
Pagination999-1006
Date Published2002 Jul
ISSN1286-4579
KeywordsAfrica, Animals, Glycosylphosphatidylinositols, Humans, Macrophage Activation, Macrophages, Trypanosoma brucei gambiense, Trypanosoma brucei rhodesiense, Trypanosomiasis, Type C Phospholipases, Vaccination, Variant Surface Glycoproteins, Trypanosoma
Abstract

African trypanosomes express a glycosylphosphatidyl inositol (GPI)-anchored variant-specific surface glycoprotein (VSG) as a protective coat. During infection, large amounts of VSG molecules are released into the circulation. Their interaction with various cells of the immune system underlies the severe infection-associated pathology. Recent results have shown that anti-GPI vaccination can prevent the occurrence of this pathology.

Alternate JournalMicrobes Infect.
PubMed ID12106794