|Title||VSG-GPI anchors of African trypanosomes: their role in macrophage activation and induction of infection-associated immunopathology.|
|Publication Type||Journal Article|
|Year of Publication||2002|
|Authors||Magez, S., B. Stijlemans, T. Nath Baral, and P. De Baetselier|
|Date Published||2002 Jul|
|Keywords||Africa, Animals, Glycosylphosphatidylinositols, Humans, Macrophage Activation, Macrophages, Trypanosoma brucei gambiense, Trypanosoma brucei rhodesiense, Trypanosomiasis, Type C Phospholipases, Vaccination, Variant Surface Glycoproteins, Trypanosoma|
African trypanosomes express a glycosylphosphatidyl inositol (GPI)-anchored variant-specific surface glycoprotein (VSG) as a protective coat. During infection, large amounts of VSG molecules are released into the circulation. Their interaction with various cells of the immune system underlies the severe infection-associated pathology. Recent results have shown that anti-GPI vaccination can prevent the occurrence of this pathology.
|Alternate Journal||Microbes Infect.|