Tumor necrosis factor alpha is a key mediator in the regulation of experimental Trypanosoma brucei infections.

TitleTumor necrosis factor alpha is a key mediator in the regulation of experimental Trypanosoma brucei infections.
Publication TypeJournal Article
Year of Publication1999
AuthorsMagez, S., M. Radwanska, A. Beschin, K. Sekikawa, and P. De Baetselier
JournalInfect Immun
Volume67
Issue6
Pagination3128-32
Date Published1999 Jun
ISSN0019-9567
KeywordsAnimals, Disease Models, Animal, Lipopolysaccharides, Mice, Mice, Inbred C57BL, Mice, Knockout, Trypanosoma brucei brucei, Trypanosomiasis, African, Tumor Necrosis Factor-alpha
Abstract

In order to evaluate during experimental Trypanosoma brucei infections the potential role of tumor necrosis factor alpha (TNF-alpha) in the host-parasite interrelationship, C57BL/6 TNF-alpha knockout mice (TNF-alpha-/-) as well as C57BL/6 wild-type mice were infected with pleomorphic T. brucei AnTat 1.1 E parasites. In the TNF-alpha-/- mice, the peak levels of parasitemia were strongly increased compared to the peak levels recorded in wild-type mice. The increased parasite burden did not reflect differences in clearance efficacy or in production of T. brucei-specific immunoglobulin M (IgM) and IgG antibodies. Trypanosome-mediated immunopathological features, such as lymph node-associated immunosuppression and lipopolysaccharide hypersensitivity, were found to be greatly reduced in infected TNF-alpha-/- mice. These results demonstrate that, during trypanosome infections, TNF-alpha is a key mediator involved in both parasitemia control and infection-associated pathology.

Alternate JournalInfect. Immun.
PubMed ID10338530
PubMed Central IDPMC96631