Intrinsically disordered proteins: a 10-year recap.

TitleIntrinsically disordered proteins: a 10-year recap.
Publication TypeJournal Article
Year of Publication2012
AuthorsTompa, P.
JournalTrends Biochem Sci
Volume37
Issue12
Pagination509-16
Date Published2012 Dec
Type of Articleidp
ISSN0968-0004
KeywordsAnimals, Drug Design, Humans, Models, Molecular, Protein Conformation, Proteins
Abstract

The suggestion that the native state of many proteins is intrinsically disordered (or, as originally termed, unstructured) is now integral to our general view of protein structure and function. A little more than 10 years ago, however, such challenge to the almost dogmatic 'structure-function paradigm' was pure heresy due to the overwhelming evidence that structure determines function. A decade of steady progress turned skepticism around: this 10-year recap review outlines the situation a decade ago and the major directions of the breathtaking advance achieved by experimental and computational approaches. I show that the evidence for the generality and importance of this phenomenon is now so insurmountable that it demands the inclusion of 'unstructural' biology into mainstream biology and biochemistry textbooks.

DOI10.1016/j.tibs.2012.08.004
Alternate JournalTrends Biochem. Sci.
PubMed ID22989858