Title | Long-range interactions in nonsense-mediated mRNA decay are mediated by intrinsically disordered protein regions. |
Publication Type | Journal Article |
Year of Publication | 2012 |
Authors | Kalmar, L., V. Acs, D. Silhavy, and P. Tompa |
Journal | J Mol Biol |
Volume | 424 |
Issue | 3-4 |
Pagination | 125-31 |
Date Published | 2012 Dec 7 |
ISSN | 1089-8638 |
Keywords | Computational Biology, Models, Biological, Multiprotein Complexes, Nonsense Mediated mRNA Decay, Protein Binding, Protein Conformation, RNA, Messenger |
Abstract | In nonsense-mediated mRNA decay (NMD), large protein complexes cooperate to trigger degradation of mRNA with a premature termination codon. Due to the extreme variation in the size and topology of its mRNA substrate, the structural underpinning of the fidelity of NMD is little understood. Based on bioinformatic predictions, we suggest that fly-casting mechanisms enabled by long disordered regions in NMD complexes are exploited for the underlying effective long-range communication. |
DOI | 10.1016/j.jmb.2012.09.002 |
Alternate Journal | J. Mol. Biol. |
PubMed ID | 22971338 |
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