Long-range interactions in nonsense-mediated mRNA decay are mediated by intrinsically disordered protein regions.

TitleLong-range interactions in nonsense-mediated mRNA decay are mediated by intrinsically disordered protein regions.
Publication TypeJournal Article
Year of Publication2012
AuthorsKalmar, L., V. Acs, D. Silhavy, and P. Tompa
JournalJ Mol Biol
Volume424
Issue3-4
Pagination125-31
Date Published2012 Dec 7
ISSN1089-8638
KeywordsComputational Biology, Models, Biological, Multiprotein Complexes, Nonsense Mediated mRNA Decay, Protein Binding, Protein Conformation, RNA, Messenger
Abstract

In nonsense-mediated mRNA decay (NMD), large protein complexes cooperate to trigger degradation of mRNA with a premature termination codon. Due to the extreme variation in the size and topology of its mRNA substrate, the structural underpinning of the fidelity of NMD is little understood. Based on bioinformatic predictions, we suggest that fly-casting mechanisms enabled by long disordered regions in NMD complexes are exploited for the underlying effective long-range communication.

DOI10.1016/j.jmb.2012.09.002
Alternate JournalJ. Mol. Biol.
PubMed ID22971338