Intrinsic disorder in cell signaling and gene transcription.

TitleIntrinsic disorder in cell signaling and gene transcription.
Publication TypeJournal Article
Year of Publication2012
AuthorsTantos, Á., Han K-H., and Tompa P.
JournalMol Cell Endocrinol
Volume348
Issue2
Pagination457-65
Date Published2012 Jan 30
ISSN1872-8057
KeywordsBinding Sites, Chromatin Assembly and Disassembly, Cytoskeletal Proteins, Humans, Intracellular Signaling Peptides and Proteins, Protein Binding, Protein Interaction Domains and Motifs, Protein Structure, Secondary, Signal Transduction, Thermodynamics, Transcription Factors, Transcription, Genetic
Abstract

Structural disorder, which enables unique modes of action often associated with molecular recognition and folding induced by a partner, is widespread in eukaryotic proteomes. Due to the ensuing advantages, such as specificity without strong binding, adaptability to multiple partners and subtle regulation by post-translational modification, structural disorder is prevalent in proteins of signaling and regulatory functions, such as membrane receptors, scaffold proteins, cytoskeletal proteins, transcription factors and nuclear hormone receptors. In this review we survey the most important aspects of structural disorder, with major focus on features and advantages pertinent to signal transduction. Our major goal is to elucidate how the functional requirements of these protein classes concur with specific functional modes disorder enables.

DOI10.1016/j.mce.2011.07.015
Alternate JournalMol. Cell. Endocrinol.
PubMed ID21782886