Power law distribution defines structural disorder as a structural element directly linked with function.

TitlePower law distribution defines structural disorder as a structural element directly linked with function.
Publication TypeJournal Article
Year of Publication2010
AuthorsTompa, P., and L. Kalmar
JournalJ Mol Biol
Volume403
Issue3
Pagination346-50
Date Published2010 Oct 29
Type of Articleidp
ISSN1089-8638
KeywordsHumans, Protein Conformation, Protein Folding, Proteins, Proteome, Structure-Activity Relationship
Abstract

Although intrinsically disordered proteins are prevalent and functionally important, it has never been asked whether structural disorder should be considered as a separate structural category on its own or merely as a lack of secondary and/or tertiary structure. We address this issue by showing that its length distribution in the human proteome follows a power law, with many short regions but also a significant incidence of very long disordered regions. This behavior is in sharp contrast with that of conventional secondary structural elements and is highly reminiscent of the distribution of tertiary structural units in proteins. We interpret this finding by the direct functional involvement of disorder, which distinguishes it from secondary structural elements and endows it with tertiary structural attributes.

DOI10.1016/j.jmb.2010.07.044
Alternate JournalJ. Mol. Biol.
PubMed ID20816987