Malleable machines take shape in eukaryotic transcriptional regulation.

TitleMalleable machines take shape in eukaryotic transcriptional regulation.
Publication TypeJournal Article
Year of Publication2008
AuthorsFuxreiter, M., P. Tompa, I. Simon, V. N. Uversky, J. C. Hansen, and F. J. Asturias
JournalNat Chem Biol
Volume4
Issue12
Pagination728-37
Date Published2008 Dec
Type of Articleidp
ISSN1552-4469
KeywordsEukaryotic Cells, Gene Expression Regulation, Macromolecular Substances, Multiprotein Complexes, Transcription, Genetic
Abstract

Transcriptional control requires the spatially and temporally coordinated action of many macromolecular complexes. Chromosomal proteins, transcription factors, co-activators and components of the general transcription machinery, including RNA polymerases, often use structurally or stoichiometrically ill-defined regions for interactions that convey regulatory information in processes ranging from chromatin remodeling to mRNA processing. Determining the functional significance of intrinsically disordered protein regions and developing conceptual models of their action will help to illuminate their key role in transcription regulation. Complexes comprising disordered regions often display short recognition elements embedded in flexible and sequentially variable environments that can lead to structural and functional malleability. This provides versatility to recognize multiple targets having different structures, facilitate conformational rearrangements and physically communicate with many partners in response to environmental changes. All these features expand the capacities of ordered complexes and give rise to efficient regulatory mechanisms.

DOI10.1038/nchembio.127
Alternate JournalNat. Chem. Biol.
PubMed ID19008886
PubMed Central IDPMC2921704
Grant ListGM071714-01A2 / GM / NIGMS NIH HHS / United States
GM45916 / GM / NIGMS NIH HHS / United States
GM66834 / GM / NIGMS NIH HHS / United States
R01 GM067167-01A1 / GM / NIGMS NIH HHS / United States
R01 LM007688-01A1 / LM / NLM NIH HHS / United States
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