DisProt: the Database of Disordered Proteins.

TitleDisProt: the Database of Disordered Proteins.
Publication TypeJournal Article
Year of Publication2007
AuthorsSickmeier, M., J. A. Hamilton, T. LeGall, V. Vacic, M. S. Cortese, Á. Tantos, B. Szabo, P. Tompa, J. Chen, V. N. Uversky, Z. Obradovic, and K. A Dunker
JournalNucleic Acids Res
IssueDatabase issue
Date Published2007 Jan
Type of Articleidp
KeywordsDatabases, Protein, Internet, Protein Conformation, Protein Folding, Proteins, User-Computer Interface

The Database of Protein Disorder (DisProt) links structure and function information for intrinsically disordered proteins (IDPs). Intrinsically disordered proteins do not form a fixed three-dimensional structure under physiological conditions, either in their entireties or in segments or regions. We define IDP as a protein that contains at least one experimentally determined disordered region. Although lacking fixed structure, IDPs and regions carry out important biological functions, being typically involved in regulation, signaling and control. Such functions can involve high-specificity low-affinity interactions, the multiple binding of one protein to many partners and the multiple binding of many proteins to one partner. These three features are all enabled and enhanced by protein intrinsic disorder. One of the major hindrances in the study of IDPs has been the lack of organized information. DisProt was developed to enable IDP research by collecting and organizing knowledge regarding the experimental characterization and the functional associations of IDPs. In addition to being a unique source of biological information, DisProt opens doors for a plethora of bioinformatics studies. DisProt is openly available at http://www.disprot.org.

Alternate JournalNucleic Acids Res.
PubMed ID17145717
PubMed Central IDPMC1751543
Grant List067595 / / Wellcome Trust / United Kingdom
R01 LM007688-01A1 / LM / NLM NIH HHS / United States