IUPred: web server for the prediction of intrinsically unstructured regions of proteins based on estimated energy content.

TitleIUPred: web server for the prediction of intrinsically unstructured regions of proteins based on estimated energy content.
Publication TypeJournal Article
Year of Publication2005
AuthorsDosztányi, Z., V. Csizmok, P. Tompa, and I. Simon
JournalBioinformatics
Volume21
Issue16
Pagination3433-4
Date Published2005 Aug 15
ISSN1367-4803
KeywordsAlgorithms, Computer Simulation, Energy Transfer, Internet, Models, Chemical, Models, Molecular, Protein Conformation, Protein Folding, Proteins, Sequence Alignment, Sequence Analysis, Protein, Software, Structure-Activity Relationship
Abstract

Intrinsically unstructured/disordered proteins and domains (IUPs) lack a well-defined three-dimensional structure under native conditions. The IUPred server presents a novel algorithm for predicting such regions from amino acid sequences by estimating their total pairwise interresidue interaction energy, based on the assumption that IUP sequences do not fold due to their inability to form sufficient stabilizing interresidue interactions. Optional to the prediction are built-in parameter sets optimized for predicting short or long disordered regions and structured domains.

DOI10.1093/bioinformatics/bti541
Alternate JournalBioinformatics
PubMed ID15955779
Grant List / / Wellcome Trust / United Kingdom