Revisiting ubiquity and tissue specificity of human calpains.

TitleRevisiting ubiquity and tissue specificity of human calpains.
Publication TypeJournal Article
Year of Publication2003
AuthorsFarkas, A., P. Tompa, and P. Friedrich
JournalBiol Chem
Volume384
Issue6
Pagination945-9
Date Published2003 Jun
ISSN1431-6730
KeywordsCalcium-Binding Proteins, Calpain, Cell Line, Gene Expression Profiling, Humans, Organ Specificity, RNA, Messenger
Abstract

The abundance of mRNAs transcribed from human genes of the calpain superfamily was studied in 72 human tissues and cell types by the Human Multiple Tissue Expression (MTE) Array technique. The analysis included the large subunits of mu- and m-calpains, the small subunits, calpastatin and calpain 3 (p94). Besides specific data on transcriptional activity, two major conclusions emerged: (i) 'ubiquitous' calpains are not expressed in all cell types, and (ii) a 'tissue-specific' calpain may be expressed in many cell types apart from the one in which it is particularly abundant. Therefore, the categoric classification of 'ubiquitous' vs. 'tissue-specific' calpains is a simplification.

DOI10.1515/BC.2003.106
Alternate JournalBiol. Chem.
PubMed ID12887062