Title | Intrinsically unstructured proteins. |
Publication Type | Journal Article |
Year of Publication | 2002 |
Authors | Tompa, P. |
Journal | Trends Biochem Sci |
Volume | 27 |
Issue | 10 |
Pagination | 527-33 |
Date Published | 2002 Oct |
ISSN | 0968-0004 |
Keywords | Amino Acid Sequence, Amino Acids, Entropy, Hydrophobic and Hydrophilic Interactions, Models, Molecular, Protein Binding, Protein Conformation, Protein Denaturation, Protein Folding, Proteins, Static Electricity, Structure-Activity Relationship |
Abstract | The recent suggestion that the classical structure-function paradigm should be extended to proteins and protein domains whose native and functional state is intrinsically unstructured has received a great deal of support. There is ample evidence that the unstructured state, common to all living organisms, is essential for basic cellular functions; thus it deserves to be recognized as a separate functional and structural category within the protein kingdom. In this review, recent findings are surveyed to illustrate that this novel but rapidly advancing field has reached a point where these proteins can be comprehensively classified on the basis of structure and function. |
Alternate Journal | Trends Biochem. Sci. |
PubMed ID | 12368089 |
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