Chemical attenuation of pilus function and assembly in Gram-negative bacteria.

TitleChemical attenuation of pilus function and assembly in Gram-negative bacteria.
Publication TypeJournal Article
Year of Publication2013
AuthorsLo, A. W. H., K. Moonens, and H. Remaut
JournalCurr Opin Microbiol
Volume16
Issue1
Pagination85-92
Date Published2013 Feb
Type of Articlesmm
ISSN1879-0364
KeywordsAnti-Bacterial Agents, Fimbriae, Bacterial, Gram-Negative Bacteria, Models, Biological, Models, Molecular, Multiprotein Complexes
Abstract

Bacteria express a multitude of hair-like adhesive appendages on their cell surfaces, together referred to as pili or fimbriae. In Gram-negative bacteria, these proteinaceous structures are assembled through a number of dedicated secretion pathways including the chaperone-usher pathway, the nucleation/precipitation pathway and the type IV pilus pathway. Pili are prevalent in pathogenic strains and play important roles in the establishment and persistence of bacterial infections by mediating host cell adhesion, cell invasion or biofilm formation. Their indispensible roles in pathogenesis render them attractive targets for directed therapeutic intervention. Here, we describe the recent advances in the chemical attenuation of pilus-associated virulence in Gram-negative bacteria.

DOI10.1016/j.mib.2013.02.003
Alternate JournalCurr. Opin. Microbiol.
PubMed ID23434114
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