Title | Fiber assembly by the chaperone-usher pathway. |
Publication Type | Journal Article |
Year of Publication | 2004 |
Authors | Sauer, F. G., H. Remaut, S. J. Hultgren, and G. Waksman |
Journal | Biochim Biophys Acta |
Volume | 1694 |
Issue | 1-3 |
Pagination | 259-67 |
Date Published | 2004 Nov 11 |
ISSN | 0006-3002 |
Keywords | Bacterial Proteins, Fimbriae Proteins, Fimbriae, Bacterial, Gram-Negative Bacteria, Molecular Chaperones, Protein Conformation |
Abstract | Bacterial pathogens utilize the chaperone-usher pathway to assemble extracellular multi-subunit fibers essential for virulence. The periplasmic chaperone facilitates the initial folding of fiber subunits but then traps them in activated folding transition states. Chaperone dissociation releases the folding energy that drives subunit incorporation into the fiber, which grows through a pore formed by the outer-membrane usher. |
DOI | 10.1016/j.bbamcr.2004.02.010 |
Alternate Journal | Biochim. Biophys. Acta |
PubMed ID | 15546670 |
Grant List | AI29549 / AI / NIAID NIH HHS / United States AI48689 / AI / NIAID NIH HHS / United States DK51406 / DK / NIDDK NIH HHS / United States DK64540 / DK / NIDDK NIH HHS / United States |
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