Therapeutic nanoreactors: combining chemistry and biology in a novel triblock copolymer drug delivery system.

TitleTherapeutic nanoreactors: combining chemistry and biology in a novel triblock copolymer drug delivery system.
Publication TypeJournal Article
Year of Publication2005
AuthorsRanquin, A., W. Versées, W. Meier, J. Steyaert, and P. Van Gelder
JournalNano Lett
Volume5
Issue11
Pagination2220-4
Date Published2005 Nov
ISSN1530-6984
KeywordsAnimals, Bacterial Outer Membrane Proteins, Bioreactors, Drug Delivery Systems, Escherichia coli Proteins, Kinetics, N-Glycosyl Hydrolases, Nanostructures, Nanotechnology, Permeability, Polymers, Porins, Prodrugs, Receptors, Virus, Trypanosoma vivax
Abstract

Triblock copolymeric nanoreactors are introduced as an alternative for liposomes as encapsulating carrier for prodrug activating enzymes. Inosine-adenosine-guanosine preferring nucleoside hydrolase of Trypanosoma vivax, a potential prodrug activating enzyme, was encapsulated in nanometer-sized vesicles constructed of poly(2-methyloxazoline)-block-poly(dimethylsiloxane)-block-(2-methyloxazoline) triblock copolymers. The nanoreactor is functionalized by incorporation of bacterial porins, OmpF or Tsx, in the reactor wall. Efficient cleavage of three natural substrates and one prodrug, 2-fluoroadenosine, by the nanoreactors was demonstrated.

DOI10.1021/nl051523d
Alternate JournalNano Lett.
PubMed ID16277457