1,2,3-Triazolylalkylribitol derivatives as nucleoside hydrolase inhibitors.

Title1,2,3-Triazolylalkylribitol derivatives as nucleoside hydrolase inhibitors.
Publication TypeJournal Article
Year of Publication2007
AuthorsGoeminne, A., M. McNaughton, G. Bal, G. Surpateanu, P. Van der Veken, S. De Prol, W. Versées, J. Steyaert, S. Apers, A. Haemers, and K. Augustyns
JournalBioorg Med Chem Lett
Date Published2007 May 1
KeywordsAnimals, Chemistry, Pharmaceutical, Drug Design, Enzyme Inhibitors, Kinetics, Models, Chemical, Molecular Conformation, N-Glycosyl Hydrolases, Ribitol, Triazoles, Trypanosoma brucei brucei

A range of novel 1,2,3-triazolylalkylribitol derivatives were synthesized and evaluated as nucleoside hydrolase inhibitors. The most active compound (11a) has low micromolar potency and is structurally diverse from previously reported nucleoside hydrolase inhibitors, which, along with the simplicity of the chemistry involved in its synthesis, makes it a good lead for the further development of novel nucleoside hydrolase inhibitors.

Alternate JournalBioorg. Med. Chem. Lett.
PubMed ID17317181