Nanobodies and their potential applications.

TitleNanobodies and their potential applications.
Publication TypeJournal Article
Year of Publication2013
AuthorsHassanzadeh-Ghassabeh, G., N. Devoogdt, P. De Pauw, C. Vincke, and S. Muyldermans
JournalNanomedicine (Lond)
Volume8
Issue6
Pagination1013-26
Date Published2013 Jun
ISSN1748-6963
KeywordsAnimals, Biosensing Techniques, Diagnostic Imaging, Humans, Nanomedicine, Single-Domain Antibodies
Abstract

Nanobodies are recombinant, antigen-specific, single-domain, variable fragments of camelid heavy chain-only antibodies. The innate supremacy of nanobodies as a renewable source of affinity reagents, together with their high production yield in a broad variety of expression systems, minimal size, great stability, reversible refolding and outstanding solubility in aqueous solutions, and ability to specifically recognize unique epitopes with subnanomolar affinity, have combined to make them a useful class of biomolecules for research and various medical diagnostic and therapeutic applications. This article speculates on a number of technological innovations that might be introduced in the nanobody identification platform to streamline the generation of more potent nanobodies and to expand their application range.

DOI10.2217/nnm.13.86
Alternate JournalNanomedicine (Lond)
PubMed ID23730699
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