Chromosome rearrangement in Leishmania mexicana M379.

TitleChromosome rearrangement in Leishmania mexicana M379.
Publication TypeJournal Article
Year of Publication1991
AuthorsLiu, J. H., N. Gajendran, D. Muthui, S. Muyldermans, J. C. Dujardin, S. De Doncker, D. Jacquet, D. Le Ray, F. Mathieu-Daudé, and R. Hamers
JournalMol Biochem Parasitol
Volume46
Issue1
Pagination53-60
Date Published1991 May
ISSN0166-6851
KeywordsAnimals, Blotting, Southern, Cloning, Molecular, DNA, Circular, DNA, Protozoan, Leishmania mexicana, Recombination, Genetic, Restriction Mapping
Abstract

Circular extrachromosomal elements were observed in a variety of Leishmania species. We show here that two lines originating from the same isolate have been found to contain a circular DNA molecule of 26.6 kb and a linear chromosome of about 250 kb, respectively, which share a homology of more than 20 kb. The circular DNA molecule and its related region on the linear chromosome were cloned and their restriction maps compared. This investigation reveals information about chromosome rearrangement in L. mexicana M379. Further examination will enable us to understand the nature of chromosome rearrangement such as circularization or linearization.

Alternate JournalMol. Biochem. Parasitol.
PubMed ID1852176