iRefWeb: interactive analysis of consolidated protein interaction data and their supporting evidence.

TitleiRefWeb: interactive analysis of consolidated protein interaction data and their supporting evidence.
Publication TypeJournal Article
Year of Publication2010
AuthorsTurner, B., Razick S., Turinsky A. L., Vlasblom J., Crowdy E. K., Cho E., Morrison K., Donaldson I. M., and Wodak S. J.
JournalDatabase (Oxford)
Volume2010
Paginationbaq023
Date Published2010
ISSN1758-0463
KeywordsAbstracting and Indexing as Topic, Animals, Computational Biology, Data Display, Database Management Systems, Databases, Protein, Humans, Information Storage and Retrieval, Internet, Protein Interaction Mapping, Proteins, User-Computer Interface
Abstract

We present iRefWeb, a web interface to protein interaction data consolidated from 10 public databases: BIND, BioGRID, CORUM, DIP, IntAct, HPRD, MINT, MPact, MPPI and OPHID. iRefWeb enables users to examine aggregated interactions for a protein of interest, and presents various statistical summaries of the data across databases, such as the number of organism-specific interactions, proteins and cited publications. Through links to source databases and supporting evidence, researchers may gauge the reliability of an interaction using simple criteria, such as the detection methods, the scale of the study (high- or low-throughput) or the number of cited publications. Furthermore, iRefWeb compares the information extracted from the same publication by different databases, and offers means to follow-up possible inconsistencies. We provide an overview of the consolidated protein-protein interaction landscape and show how it can be automatically cropped to aid the generation of meaningful organism-specific interactomes. iRefWeb can be accessed at: http://wodaklab.org/iRefWeb. Database URL: http://wodaklab.org/iRefWeb/

DOI10.1093/database/baq023
Alternate JournalDatabase (Oxford)
PubMed ID20940177
PubMed Central IDPMC2963317
Grant ListMOP#82940 / / Canadian Institutes of Health Research / Canada