Amino acid sequence templates derived from recurrent turn motifs in proteins: critical evaluation of their predictive power.

TitleAmino acid sequence templates derived from recurrent turn motifs in proteins: critical evaluation of their predictive power.
Publication TypeJournal Article
Year of Publication1989
AuthorsRooman, M. J., Wodak S. J., and Thornton J. M.
JournalProtein Eng
Volume3
Issue1
Pagination23-7
Date Published1989 Oct
ISSN0269-2139
KeywordsAmino Acid Sequence, Computer Graphics, Computer Simulation, Information Systems, Models, Molecular, Protein Conformation, Templates, Genetic
Abstract

Amino acid sequence patterns suggested to characterize specific recurrent turn conformation in protein are tested as to their predictive power in a database containing 75 proteins of known structure. Many of these patterns are found to be associated with local structures that differ from the motifs originally used to derive them. It is therefore concluded that, while they could be useful for improving predictions made by other methods, their stand-alone predictive power is poor. The issue of deriving and validating consensus sequence patterns for use in protein structure prediction is raised.

Alternate JournalProtein Eng.
PubMed ID2813339