Copper-catalyzed oxidative ring closure and carboarylation of 2-ethynylanilides.

TitleCopper-catalyzed oxidative ring closure and carboarylation of 2-ethynylanilides.
Publication TypeJournal Article
Year of Publication2013
AuthorsSinai, Á., Á. Mészáros, T. Gáti, V. Kudar, A. Palló, and Z. Novák
JournalOrg Lett
Volume15
Issue22
Pagination5654-7
Date Published2013 Nov 15
ISSN1523-7052
Abstract

A new copper-catalyzed oxidative ring closure of ethynyl anilides with diaryliodonium salts was developed for the highly modular construction of benzoxazines bearing a fully substituted exo double bond. The oxidative transformation includes an unusual 6-exo-dig cyclization step with the formation of C-O and C-C bonds.

DOI10.1021/ol402600r
Alternate JournalOrg. Lett.
PubMed ID24188109