TAsystems

Toxin-antitoxin systems

Production, biophysical characterization and crystallization of Pseudomonas putida GraA and its complexes with GraT and the graTA operator.

Talavera, A., H. Tamman, A. Ainelo, S. Hadǽi, A. Garcia-Pino, R. Hõrak, A. Konijnenberg, and R. Loris, "Production, biophysical characterization and crystallization of Pseudomonas putida GraA and its complexes with GraT and the graTA operator.", Acta Crystallogr F Struct Biol Commun, vol. 73, issue Pt 8, pp. 455-462, 2017 Aug 01.

A unique hetero-hexadecameric architecture displayed by the Escherichia coli O157 PaaA2-ParE2 antitoxin-toxin complex.

Sterckx, Y. G. - J., T. Jové, A. V. Shkumatov, A. Garcia-Pino, L. Geerts, M. De Kerpel, J. Lah, H. De Greve, L. Van Melderen, and R. Loris, "A unique hetero-hexadecameric architecture displayed by the Escherichia coli O157 PaaA2-ParE2 antitoxin-toxin complex.", J Mol Biol, vol. 428, issue 8, pp. 1589-603, 2016 Apr 24.

Structural Mimicry of Receptor Interaction by Antagonistic Interleukin-6 (IL-6) Antibodies.

Blanchetot, C., N. De Jonge, A. Desmyter, N. Ongenae, E. Hofman, A. Klarenbeek, A. Sadi, A. Hultberg, A. Kretz-Rommel, S. Spinelli, et al., "Structural Mimicry of Receptor Interaction by Antagonistic Interleukin-6 (IL-6) Antibodies.", J Biol Chem, vol. 291, issue 26, pp. 13846-54, 2016 Jun 24.

Frizzled 7 and PIP2 binding by syntenin PDZ2 domain supports Frizzled 7 trafficking and signalling.

Egea-Jimenez, A. Luis, R. Gallardo, A. Garcia-Pino, Y. Ivarsson, A. Maria Wawrzyniak, R. Kashyap, R. Loris, J. Schymkowitz, F. Rousseau, and P. Zimmermann, "Frizzled 7 and PIP2 binding by syntenin PDZ2 domain supports Frizzled 7 trafficking and signalling.", Nat Commun, vol. 7, pp. 12101, 2016 07 08.

An efficient method for the purification of proteins from four distinct toxin-antitoxin modules.

Sterckx, Y. G. - J., S. De Gieter, V. Zorzini, S. Hadži, S. Haesaerts, R. Loris, and A. Garcia-Pino, "An efficient method for the purification of proteins from four distinct toxin-antitoxin modules.", Protein Expr Purif, vol. 108, pp. 30-40, 2015 Apr.

Crystallization of two operator complexes from the Vibrio cholerae HigBA2 toxin-antitoxin module.

Hadži, S., A. Garcia-Pino, K. Gerdes, J. Lah, and R. Loris, "Crystallization of two operator complexes from the Vibrio cholerae HigBA2 toxin-antitoxin module.", Acta Crystallogr F Struct Biol Commun, vol. 71, issue Pt 2, pp. 226-33, 2015 Feb.

Crystallization and preliminary X-ray analysis of four cysteine proteases from Ficus carica latex.

Haesaerts, S., J. Alexander Buitrago, R. Loris, D. Baeyens-Volant, and M. Azarkan, "Crystallization and preliminary X-ray analysis of four cysteine proteases from Ficus carica latex.", Acta Crystallogr F Struct Biol Commun, vol. 71, issue Pt 4, pp. 459-65, 2015 Apr.

Escherichia coli antitoxin MazE as transcription factor: insights into MazE-DNA binding.

Zorzini, V., L. Buts, E. Schrank, Y. G. J. Sterckx, M. Respondek, H. Engelberg-Kulka, R. Loris, K. Zangger, and N. A. J. van Nuland, "Escherichia coli antitoxin MazE as transcription factor: insights into MazE-DNA binding.", Nucleic Acids Res, vol. 43, issue 2, pp. 1241-56, 2015 Jan.

The intrinsically disordered domain of the antitoxin Phd chaperones the toxin Doc against irreversible inactivation and misfolding.

De Gieter, S., A. Konijnenberg, A. Talavera, A. Butterer, S. Haesaerts, H. De Greve, F. Sobott, R. Loris, and A. Garcia-Pino, "The intrinsically disordered domain of the antitoxin Phd chaperones the toxin Doc against irreversible inactivation and misfolding.", J Biol Chem, vol. 289, issue 49, pp. 34013-23, 2014 Dec 05.

A nanobody modulates the p53 transcriptional program without perturbing its functional architecture.

Bethuyne, J., S. De Gieter, O. Zwaenepoel, A. Garcia-Pino, K. Durinck, A. Verhelle, G. Hassanzadeh-Ghassabeh, F. Speleman, R. Loris, and J. Gettemans, "A nanobody modulates the p53 transcriptional program without perturbing its functional architecture.", Nucleic Acids Res, vol. 42, issue 20, pp. 12928-38, 2014 Nov 10.

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