Nanobodies

Nanobody production and applications

Structures of β-klotho reveal a 'zip code'-like mechanism for endocrine FGF signalling.

Lee, S., Choi J., Mohanty J., Sousa L. P., Tome F., Pardon E., Steyaert J., Lemmon M. A., Lax I., and Schlessinger J., "Structures of β-klotho reveal a 'zip code'-like mechanism for endocrine FGF signalling.", Nature, vol. 553, issue 7689, pp. 501-505, 2018 01 25.

Binding-Site Compatible Fragment Growing Applied to the Design of β-Adrenergic Receptor Ligands.

Chevillard, F., Rimmer H., Betti C., Pardon E., Ballet S., van Hilten N., Steyaert J., Diederich W. E., and Kolb P., "Binding-Site Compatible Fragment Growing Applied to the Design of β-Adrenergic Receptor Ligands.", J Med Chem, vol. 61, issue 3, pp. 1118-1129, 2018 Feb 08.

Mutational analysis of the extracellular disulphide bridges of the atypical chemokine receptor ACKR3/CXCR7 uncovers multiple binding and activation modes for its chemokine and endogenous non-chemokine agonists.

Szpakowska, M., Meyrath M., Reynders N., Counson M., Hanson J., Steyaert J., and Chevigné A., "Mutational analysis of the extracellular disulphide bridges of the atypical chemokine receptor ACKR3/CXCR7 uncovers multiple binding and activation modes for its chemokine and endogenous non-chemokine agonists.", Biochem Pharmacol, vol. 153, pp. 299-309, 2018 Jul.

Binding Specificities of Nanobody•Membrane Protein Complexes Obtained from Chemical Cross-Linking and High-Mass MALDI Mass Spectrometry.

Köhler, M., Neff C., Perez C., Brunner C., Pardon E., Steyaert J., Schneider G., Locher K. P., and Zenobi R., "Binding Specificities of Nanobody•Membrane Protein Complexes Obtained from Chemical Cross-Linking and High-Mass MALDI Mass Spectrometry.", Anal Chem, vol. 90, issue 8, pp. 5306-5313, 2018 Apr 17.

Correction to Discovery, Structure-Activity Relationship, and Binding Mode of an Imidazo[1,2- a]pyridine Series of Autotaxin Inhibitors.

Joncour, A., Desroy N., Housseman C., Bock X., Bienvenu N., Cherel L., Labeguere V., Peixoto C., Annoot D., Lepissier L., et al., "Correction to Discovery, Structure-Activity Relationship, and Binding Mode of an Imidazo[1,2- a]pyridine Series of Autotaxin Inhibitors.", J Med Chem, vol. 61, issue 9, pp. 4270, 2018 May 10.

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