Nanobodies

Nanobody production and applications

Nanobodies to Study G Protein-Coupled Receptor Structure and Function.

Manglik, A., Kobilka B. K., and Steyaert J., "Nanobodies to Study G Protein-Coupled Receptor Structure and Function.", Annu Rev Pharmacol Toxicol, vol. 57, pp. 19-37, 2017 Jan 06.

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Quiescin-sulfhydryl oxidase inhibits prion formation in vitro.

Zhan, Y-A., Abskharon R., Li Y., Yuan J., Zeng L., Dang J., Martinez M. Camacho, Wang Z., Mikol J., Lehmann S., et al., "Quiescin-sulfhydryl oxidase inhibits prion formation in vitro.", Aging (Albany NY), vol. 8, issue 12, pp. 3419-3429, 2016 Dec 11.

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Distinct conformations of GPCR-β-arrestin complexes mediate desensitization, signaling, and endocytosis.

Cahill, T. J., Thomsen A. R. B., Tarrasch J. T., Plouffe B., Nguyen A. H., Yang F., Huang L-Y., Kahsai A. W., Bassoni D. L., Gavino B. J., et al., "Distinct conformations of GPCR-β-arrestin complexes mediate desensitization, signaling, and endocytosis.", Proc Natl Acad Sci U S A, vol. 114, issue 10, pp. 2562-2567, 2017 Mar 07.

Structural analysis of the interaction between spiroisoxazoline SMARt-420 and the Mycobacterium tuberculosis repressor EthR2.

Wohlkonig, A., Remaut H., Moune M., Tanina A., Meyer F., Desroses M., Steyaert J., Willand N., Baulard A. R., and Wintjens R., "Structural analysis of the interaction between spiroisoxazoline SMARt-420 and the Mycobacterium tuberculosis repressor EthR2.", Biochem Biophys Res Commun, vol. 487, issue 2, pp. 403-408, 2017 May 27.

Structural basis of inhibition of lipid-linked oligosaccharide flippase PglK by a conformational nanobody.

Perez, C., Köhler M., Janser D., Pardon E., Steyaert J., Zenobi R., and Locher K. P., "Structural basis of inhibition of lipid-linked oligosaccharide flippase PglK by a conformational nanobody.", Sci Rep, vol. 7, pp. 46641, 2017 Apr 19.

Leishmania donovani tyrosyl-tRNA synthetase structure in complex with a tyrosyl adenylate analog and comparisons with human and protozoan counterparts.

Barros-Álvarez, X., Kerchner K. M., Koh C. Yeow, Turley S., Pardon E., Steyaert J., Ranade R. M., J Gillespie R., Zhang Z., Verlinde C. L. M. J., et al., "Leishmania donovani tyrosyl-tRNA synthetase structure in complex with a tyrosyl adenylate analog and comparisons with human and protozoan counterparts.", Biochimie, vol. 138, pp. 124-136, 2017 Jul.

A specific nanobody prevents amyloidogenesis of D76N β2-microglobulin in vitro and modifies its tissue distribution in vivo.

Raimondi, S., Porcari R., P Mangione P., Verona G., Marcoux J., Giorgetti S., Taylor G. W., Ellmerich S., Ballico M., Zanini S., et al., "A specific nanobody prevents amyloidogenesis of D76N β2-microglobulin in vitro and modifies its tissue distribution in vivo.", Sci Rep, vol. 7, pp. 46711, 2017 Apr 21.

Rational Design of Nanobody80 Loop Peptidomimetics: Towards Biased β2 Adrenergic Receptor Ligands.

Martin, C., Moors S. L. C., Danielsen M., Betti C., Fabris C., Pedersen D. Sejer, Pardon E., Peyressatre M., Fehér K., Martins J. C., et al., "Rational Design of Nanobody80 Loop Peptidomimetics: Towards Biased β2 Adrenergic Receptor Ligands.", Chemistry, vol. 23, issue 40, pp. 9632-9640, 2017 Jul 18.

Antibodies targeting G protein-coupled receptors: Recent advances and therapeutic challenges.

Ayoub, M. Akli, Crépieux P., Koglin M., Parmentier M., Pin J-P., Poupon A., Reiter E., Smit M., Steyaert J., Watier H., et al., "Antibodies targeting G protein-coupled receptors: Recent advances and therapeutic challenges.", MAbs, vol. 9, issue 5, pp. 735-741, 2017 Jul.

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Crystallographic and biochemical characterization of the dimeric architecture of site-2 protease.

Schacherl, M., Gompert M., Pardon E., Lamkemeyer T., Steyaert J., and Baumann U., "Crystallographic and biochemical characterization of the dimeric architecture of site-2 protease.", Biochim Biophys Acta, vol. 1859, issue 10, pp. 1859-1871, 2017 10.

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