Nanobodies

Nanobody production and applications

Crystallographic and biochemical characterization of the dimeric architecture of site-2 protease.

Schacherl, M., M. Gompert, E. Pardon, T. Lamkemeyer, J. Steyaert, and U. Baumann, "Crystallographic and biochemical characterization of the dimeric architecture of site-2 protease.", Biochim Biophys Acta Biomembr, vol. 1859, issue 10, pp. 1859-1871, 2017 Oct.

Generation and Characterization of Anti-VGLUT Nanobodies Acting as Inhibitors of Transport.

Schenck, S., L. Kunz, D. Sahlender, E. Pardon, E. R. Geertsma, I. Savtchouk, T. Suzuki, Y. Neldner, S. Štefanić, J. Steyaert, et al., "Generation and Characterization of Anti-VGLUT Nanobodies Acting as Inhibitors of Transport.", Biochemistry, vol. 56, issue 30, pp. 3962-3971, 2017 08 01.

Soluble polymorphic bank vole prion proteins induced by co-expression of quiescin sulfhydryl oxidase in E. coli and their aggregation behaviors.

Abskharon, R., J. Dang, A. Elfarash, Z. Wang, P. Shen, L. S. Zou, S. Hassan, F. Wang, H. Fujioka, J. Steyaert, et al., "Soluble polymorphic bank vole prion proteins induced by co-expression of quiescin sulfhydryl oxidase in E. coli and their aggregation behaviors.", Microb Cell Fact, vol. 16, issue 1, pp. 170, 2017 Oct 04.

Discovery, Structure-Activity Relationship, and Binding Mode of an Imidazo[1,2-a]pyridine Series of Autotaxin Inhibitors.

Joncour, A., N. Desroy, C. Housseman, X. Bock, N. Bienvenu, L. Cherel, V. Labeguere, C. Peixoto, D. Annoot, L. Lepissier, et al., "Discovery, Structure-Activity Relationship, and Binding Mode of an Imidazo[1,2-a]pyridine Series of Autotaxin Inhibitors.", J Med Chem, vol. 60, issue 17, pp. 7371-7392, 2017 Sep 14.

Sortase A-mediated site-specific labeling of camelid single-domain antibody-fragments: a versatile strategy for multiple molecular imaging modalities.

Massa, S., N. Vikani, C. Betti, S. Ballet, S. Vanderhaegen, J. Steyaert, B. Descamps, C. Vanhove, A. Bunschoten, F. W. B. van Leeuwen, et al., "Sortase A-mediated site-specific labeling of camelid single-domain antibody-fragments: a versatile strategy for multiple molecular imaging modalities.", Contrast Media Mol Imaging, vol. 11, issue 5, pp. 328-339, 2016 09.

Modular Integrated Secretory System Engineering in Pichia pastoris To Enhance G-Protein Coupled Receptor Expression.

Claes, K., K. Vandewalle, B. Laukens, T. Laeremans, O. Vosters, I. Langer, M. Parmentier, J. Steyaert, and N. Callewaert, "Modular Integrated Secretory System Engineering in Pichia pastoris To Enhance G-Protein Coupled Receptor Expression.", ACS Synth Biol, vol. 5, issue 10, pp. 1070-1075, 2016 10 21.

Internalized Receptor for Glucose-dependent Insulinotropic Peptide stimulates adenylyl cyclase on early endosomes.

Ismail, S., M-J. Gherardi, A. Froese, M. Zanoun, V. Gigoux, P. Clerc, F. Gaits-Iacovoni, J. Steyaert, V. O. Nikolaev, and D. Fourmy, "Internalized Receptor for Glucose-dependent Insulinotropic Peptide stimulates adenylyl cyclase on early endosomes.", Biochem Pharmacol, vol. 120, pp. 33-45, 2016 Nov 15.

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