Nanobodies

Nanobody production and applications

Molecular imaging with macrophage CRIg-targeting nanobodies for early and preclinical diagnosis in a mouse model of rheumatoid arthritis.

Zheng, F., S. Put, L. Bouwens, T. Lahoutte, P. Matthys, S. Muyldermans, P. De Baetselier, N. Devoogdt, G. Raes, and S. Schoonooghe, "Molecular imaging with macrophage CRIg-targeting nanobodies for early and preclinical diagnosis in a mouse model of rheumatoid arthritis.", J Nucl Med, vol. 55, issue 5, pp. 824-9, 2014 May.

Specific targeting of atherosclerotic plaques in ApoE(-/-) mice using a new Camelid sdAb binding the vulnerable plaque marker LOX-1.

De Vos, J., I. Mathijs, C. Xavier, S. Massa, U. Wernery, L. Bouwens, T. Lahoutte, S. Muyldermans, and N. Devoogdt, "Specific targeting of atherosclerotic plaques in ApoE(-/-) mice using a new Camelid sdAb binding the vulnerable plaque marker LOX-1.", Mol Imaging Biol, vol. 16, issue 5, pp. 690-8, 2014 Oct.

Generation and characterization of nanobodies targeting PSMA for molecular imaging of prostate cancer.

Evazalipour, M., M. D'huyvetter, B. Soltani Tehrani, M. Abolhassani, K. Omidfar, S. Abdoli, R. Arezumand, H. Morovvati, T. Lahoutte, S. Muyldermans, et al., "Generation and characterization of nanobodies targeting PSMA for molecular imaging of prostate cancer.", Contrast Media Mol Imaging, vol. 9, issue 3, pp. 211-20, 2014 May-Jun.

Site-specific labeling of cysteine-tagged camelid single-domain antibody-fragments for use in molecular imaging.

Massa, S., C. Xavier, J. De Vos, V. Caveliers, T. Lahoutte, S. Muyldermans, and N. Devoogdt, "Site-specific labeling of cysteine-tagged camelid single-domain antibody-fragments for use in molecular imaging.", Bioconjug Chem, vol. 25, issue 5, pp. 979-88, 2014 May 21.

Expression, purification and X-ray crystallographic analysis of the Helicobacter pylori blood group antigen-binding adhesin BabA.

Subedi, S., K. Moonens, E. Romão, A. Lo, G. Vandenbussche, J. Bugaytsova, S. Muyldermans, T. Borén, and H. Remaut, "Expression, purification and X-ray crystallographic analysis of the Helicobacter pylori blood group antigen-binding adhesin BabA.", Acta Crystallogr F Struct Biol Commun, vol. 70, issue Pt 12, pp. 1631-5, 2014 Dec 01.

Single-domain antibodies targeting neuraminidase protect against an H5N1 influenza virus challenge.

Cardoso, F. Miguel, L. Itatí Ibañez, S. Van den Hoecke, S. De Baets, A. Smet, K. Roose, B. Schepens, F. J. Descamps, W. Fiers, S. Muyldermans, et al., "Single-domain antibodies targeting neuraminidase protect against an H5N1 influenza virus challenge.", J Virol, vol. 88, issue 15, pp. 8278-96, 2014 Aug.

A camelid antibody candidate for development of a therapeutic agent against Hemiscorpius lepturus envenomation.

Yardehnavi, N., M. Behdani, K. Pooshang Bagheri, A. Mahmoodzadeh, H. Khanahmad, D. Shahbazzadeh, M. Habibi-Anbouhi, G. Hassanzade Ghassabeh, and S. Muyldermans, "A camelid antibody candidate for development of a therapeutic agent against Hemiscorpius lepturus envenomation.", FASEB J, 2014 Jun 2.

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