Nanobodies

Nanobody production and applications

A nanobody binding to non-amyloidogenic regions of the protein human lysozyme enhances partial unfolding but inhibits amyloid fibril formation.

De Genst, E., P-H. Chan, E. Pardon, S-T. D. Hsu, J. R. Kumita, J. Christodoulou, L. Menzer, D. Y. Chirgadze, C. V. Robinson, S. Muyldermans, et al., "A nanobody binding to non-amyloidogenic regions of the protein human lysozyme enhances partial unfolding but inhibits amyloid fibril formation.", J Phys Chem B, vol. 117, issue 42, pp. 13245-58, 2013 Oct 24.

Imaging and radioimmunotherapy of multiple myeloma with anti-idiotypic Nanobodies.

Lemaire, M., M. D'Huyvetter, T. Lahoutte, E. Van Valckenborgh, E. Menu, E. De Bruyne, P. Kronenberger, U. Wernery, S. Muyldermans, N. Devoogdt, et al., "Imaging and radioimmunotherapy of multiple myeloma with anti-idiotypic Nanobodies.", Leukemia, vol. 28, issue 2, pp. 444-7, 2014 Feb.

The genome-wide binding profile of the Sulfolobus solfataricus transcription factor Ss-LrpB shows binding events beyond direct transcription regulation.

Nguyen-Duc, T., L. van Oeffelen, N. Song, G. Hassanzadeh-Ghassabeh, S. Muyldermans, D. Charlier, and E. Peeters, "The genome-wide binding profile of the Sulfolobus solfataricus transcription factor Ss-LrpB shows binding events beyond direct transcription regulation.", BMC Genomics, vol. 14, pp. 828, 2013.

Identification of a novel, nanobody-induced, mechanism of TAFI inactivation and its in vivo application.

Hendrickx, M. L. V., M. Zatloukalova, G. Hassanzadeh-Ghassabeh, S. Muyldermans, A. Gils, and P. J. Declerck, "Identification of a novel, nanobody-induced, mechanism of TAFI inactivation and its in vivo application.", J Thromb Haemost, vol. 12, issue 2, pp. 229-36, 2014 Feb.

In vitro and in vivo characterisation of the profibrinolytic effect of an inhibitory anti-rat TAFI nanobody.

Hendrickx, M. L. V., M. Zatloukalova, G. Hassanzadeh-Ghassabeh, S. Muyldermans, A. Gils, and P. J. Declerck, "In vitro and in vivo characterisation of the profibrinolytic effect of an inhibitory anti-rat TAFI nanobody.", Thromb Haemost, vol. 111, issue 5, pp. 824-32, 2014 May 5.

Structure of cyclin G-associated kinase (GAK) trapped in different conformations using nanobodies.

Chaikuad, A., T. Keates, C. Vincke, M. Kaufholz, M. Zenn, B. Zimmermann, C. Gutiérrez, R-G. Zhang, C. Hatzos-Skintges, A. Joachimiak, et al., "Structure of cyclin G-associated kinase (GAK) trapped in different conformations using nanobodies.", Biochem J, vol. 459, issue 1, pp. 59-69, 2014 Apr 1.

Probing the N-terminal β-sheet conversion in the crystal structure of the human prion protein bound to a nanobody.

Abskharon, R. N. N., G. Giachin, A. Wohlkonig, S. H. Soror, E. Pardon, G. Legname, and J. Steyaert, "Probing the N-terminal β-sheet conversion in the crystal structure of the human prion protein bound to a nanobody.", J Am Chem Soc, vol. 136, issue 3, pp. 937-44, 2014 Jan 22.

Pages

Subscribe to RSS - Nanobodies