Nanobodies

Nanobody production and applications

Imaging and radioimmunotherapy of multiple myeloma with anti-idiotypic Nanobodies.

Lemaire, M., M. D'Huyvetter, T. Lahoutte, E. Van Valckenborgh, E. Menu, E. De Bruyne, P. Kronenberger, U. Wernery, S. Muyldermans, N. Devoogdt, et al., "Imaging and radioimmunotherapy of multiple myeloma with anti-idiotypic Nanobodies.", Leukemia, vol. 28, issue 2, pp. 444-7, 2014 Feb.

The genome-wide binding profile of the Sulfolobus solfataricus transcription factor Ss-LrpB shows binding events beyond direct transcription regulation.

Nguyen-Duc, T., L. van Oeffelen, N. Song, G. Hassanzadeh-Ghassabeh, S. Muyldermans, D. Charlier, and E. Peeters, "The genome-wide binding profile of the Sulfolobus solfataricus transcription factor Ss-LrpB shows binding events beyond direct transcription regulation.", BMC Genomics, vol. 14, pp. 828, 2013.

Identification of a novel, nanobody-induced, mechanism of TAFI inactivation and its in vivo application.

Hendrickx, M. L. V., M. Zatloukalova, G. Hassanzadeh-Ghassabeh, S. Muyldermans, A. Gils, and P. J. Declerck, "Identification of a novel, nanobody-induced, mechanism of TAFI inactivation and its in vivo application.", J Thromb Haemost, vol. 12, issue 2, pp. 229-36, 2014 Feb.

In vitro and in vivo characterisation of the profibrinolytic effect of an inhibitory anti-rat TAFI nanobody.

Hendrickx, M. L. V., M. Zatloukalova, G. Hassanzadeh-Ghassabeh, S. Muyldermans, A. Gils, and P. J. Declerck, "In vitro and in vivo characterisation of the profibrinolytic effect of an inhibitory anti-rat TAFI nanobody.", Thromb Haemost, vol. 111, issue 5, pp. 824-32, 2014 May 5.

Structure of cyclin G-associated kinase (GAK) trapped in different conformations using nanobodies.

Chaikuad, A., T. Keates, C. Vincke, M. Kaufholz, M. Zenn, B. Zimmermann, C. Gutiérrez, R-G. Zhang, C. Hatzos-Skintges, A. Joachimiak, et al., "Structure of cyclin G-associated kinase (GAK) trapped in different conformations using nanobodies.", Biochem J, vol. 459, issue 1, pp. 59-69, 2014 Apr 1.

Probing the N-terminal β-sheet conversion in the crystal structure of the human prion protein bound to a nanobody.

Abskharon, R. N. N., G. Giachin, A. Wohlkonig, S. H. Soror, E. Pardon, G. Legname, and J. Steyaert, "Probing the N-terminal β-sheet conversion in the crystal structure of the human prion protein bound to a nanobody.", J Am Chem Soc, vol. 136, issue 3, pp. 937-44, 2014 Jan 22.

Regulation of β2-adrenergic receptor function by conformationally selective single-domain intrabodies.

Staus, D. P., L. M. Wingler, R. T. Strachan, S. G. F. Rasmussen, E. Pardon, S. Ahn, J. Steyaert, B. K. Kobilka, and R. J. Lefkowitz, "Regulation of β2-adrenergic receptor function by conformationally selective single-domain intrabodies.", Mol Pharmacol, vol. 85, issue 3, pp. 472-81, 2014 Mar.

Mechanistic analysis of allosteric and non-allosteric effects arising from nanobody binding to two epitopes of the dihydrofolate reductase of Escherichia coli.

Oyen, D., R. Wechselberger, V. Srinivasan, J. Steyaert, and J. N. Barlow, "Mechanistic analysis of allosteric and non-allosteric effects arising from nanobody binding to two epitopes of the dihydrofolate reductase of Escherichia coli.", Biochim Biophys Acta, vol. 1834, issue 10, pp. 2147-57, 2013 Oct.

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