Nanobodies

Nanobody production and applications

Structural flexibility of the G alpha s alpha-helical domain in the beta2-adrenoceptor Gs complex.

Westfield, G. H., S. G. F. Rasmussen, M. Su, S. Dutta, B. T. Devree, K. Young Chung, D. Calinski, G. Velez-Ruiz, A. N. Oleskie, E. Pardon, et al., "Structural flexibility of the G alpha s alpha-helical domain in the beta2-adrenoceptor Gs complex.", Proc Natl Acad Sci U S A, vol. 108, issue 38, pp. 16086-91, 2011 Sep 20.

Atomic structure of a nanobody-trapped domain-swapped dimer of an amyloidogenic beta2-microglobulin variant.

Domanska, K., S. Vanderhaegen, V. Srinivasan, E. Pardon, F. Dupeux, J. A. Marquez, S. Giorgetti, M. Stoppini, L. Wyns, V. Bellotti, et al., "Atomic structure of a nanobody-trapped domain-swapped dimer of an amyloidogenic beta2-microglobulin variant.", Proc Natl Acad Sci U S A, vol. 108, issue 4, pp. 1314-9, 2011 Jan 25.

Structure of a nanobody-stabilized active state of the β(2) adrenoceptor.

Rasmussen, S. G. F., H-J. Choi, J. Jose Fung, E. Pardon, P. Casarosa, P. Seok Chae, B. T. Devree, D. M. Rosenbaum, F. Sun Thian, T. Sun Kobilka, et al., "Structure of a nanobody-stabilized active state of the β(2) adrenoceptor.", Nature, vol. 469, issue 7329, pp. 175-80, 2011 Jan 13.

SbsB structure and lattice reconstruction unveil Ca2+ triggered S-layer assembly.

Baranova, E., R. Fronzes, A. Garcia-Pino, N. Van Gerven, D. Papapostolou, G. Péhau-Arnaudet, E. Pardon, J. Steyaert, S. Howorka, and H. Remaut, "SbsB structure and lattice reconstruction unveil Ca2+ triggered S-layer assembly.", Nature, vol. 487, issue 7405, pp. 119-22, 2012 Jul 5.

Experimental therapy of African trypanosomiasis with a nanobody-conjugated human trypanolytic factor.

Baral, T. Nath, S. Magez, B. Stijlemans, K. Conrath, B. Vanhollebeke, E. Pays, S. Muyldermans, and P. De Baetselier, "Experimental therapy of African trypanosomiasis with a nanobody-conjugated human trypanolytic factor.", Nat Med, vol. 12, issue 5, pp. 580-4, 2006 May.

Molecular basis for the preferential cleft recognition by dromedary heavy-chain antibodies.

De Genst, E., K. Silence, K. Decanniere, K. Conrath, R. Loris, J. Kinne, S. Muyldermans, and L. Wyns, "Molecular basis for the preferential cleft recognition by dromedary heavy-chain antibodies.", Proc Natl Acad Sci U S A, vol. 103, issue 12, pp. 4586-91, 2006 Mar 21.

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