Jan Steyaert

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2013
Kruse, A. C., Ring A. M., Manglik A., Hu J., Hu K., Eitel K., Hübner H., Pardon E., Valant C., Sexton P. M., et al., "Activation and allosteric modulation of a muscarinic acetylcholine receptor.", Nature, vol. 504, issue 7478, pp. 101-6, 2013 Dec 05.
Sohier, J. S., Laurent C., Chevigné A., Pardon E., Srinivasan V., Wernery U., Lassaux P., Steyaert J., and Galleni M., "Allosteric inhibition of VIM metallo-β-lactamases by a camelid nanobody.", Biochem J, vol. 450, issue 3, pp. 477-86, 2013 Mar 15.
Irannejad, R., Tomshine J. C., Tomshine J. R., Chevalier M., Mahoney J. P., Steyaert J., Rasmussen S. G. F., Sunahara R. K., El-Samad H., Huang B., et al., "Conformational biosensors reveal GPCR signalling from endosomes.", Nature, vol. 495, issue 7442, pp. 534-8, 2013 Mar 28.
Vercruysse, T., Boons E., Venken T., Vanstreels E., Voet A., Steyaert J., De Maeyer M., and Daelemans D., "Mapping the binding interface between an HIV-1 inhibiting intrabody and the viral protein Rev.", PLoS One, vol. 8, issue 4, pp. e60259, 2013.
Banner, D. W., Gsell B., Benz J., Bertschinger J., Burger D., Brack S., Cuppuleri S., Debulpaep M., Gast A., Grabulovski D., et al., "Mapping the conformational space accessible to BACE2 using surface mutants and cocrystals with Fab fragments, Fynomers and Xaperones.", Acta Crystallogr D Biol Crystallogr, vol. 69, issue Pt 6, pp. 1124-37, 2013 Jun.
Oyen, D., Wechselberger R., Srinivasan V., Steyaert J., and Barlow J. N., "Mechanistic analysis of allosteric and non-allosteric effects arising from nanobody binding to two epitopes of the dihydrofolate reductase of Escherichia coli.", Biochim Biophys Acta, vol. 1834, issue 10, pp. 2147-57, 2013 Oct.
Guilliams, T., El-Turk F., Buell A. K., O'Day E. M., Aprile F. A., Esbjörner E. K., Vendruscolo M., Cremades N., Pardon E., Wyns L., et al., "Nanobodies raised against monomeric α-synuclein distinguish between fibrils at different maturation stages.", J Mol Biol, vol. 425, issue 14, pp. 2397-411, 2013 Jul 24.
Löw, C., Yau Y. Hoe, Pardon E., Jegerschöld C., Wåhlin L., Quistgaard E. M., Moberg P., Geifman-Shochat S., Steyaert J., and Nordlund P., "Nanobody mediated crystallization of an archeal mechanosensitive channel.", PLoS One, vol. 8, issue 10, pp. e77984, 2013.
Vuchelen, A., Pardon E., Steyaert J., Gamain B., Loris R., van Nuland N. A. J., and Ramboarina S., "Production, crystallization and X-ray diffraction analysis of two nanobodies against the Duffy binding-like (DBL) domain DBL6ℇ-FCR3 of the Plasmodium falciparum VAR2CSA protein. Corrigendum.", Acta Crystallogr Sect F Struct Biol Cryst Commun, vol. 69, issue Pt 11, pp. 1312, 2013 Nov.
Vuchelen, A., Pardon E., Steyaert J., Gamain B., Loris R., van Nuland N. A. J., and Ramboarina S., "Production, crystallization and X-ray diffraction analysis of two nanobodies against the Duffy binding-like (DBL) domain DBL6ℇ-FCR3 of the Plasmodium falciparum VAR2CSA protein.", Acta Crystallogr Sect F Struct Biol Cryst Commun, vol. 69, issue Pt 3, pp. 270-4, 2013 Mar 1.
Yuan, J., Zhan Y-A., Abskharon R., Xiao X., Martinez M. Camacho, Zhou X., Kneale G., Mikol J., Lehmann S., Surewicz W. K., et al., "Recombinant human prion protein inhibits prion propagation in vitro.", Sci Rep, vol. 3, pp. 2911, 2013.
Vanderhaegen, S., Fislage M., Domanska K., Versées W., Pardon E., Bellotti V., and Steyaert J., "Structure of an early native-like intermediate of β2-microglobulin amyloidogenesis.", Protein Sci, vol. 22, issue 10, pp. 1349-57, 2013 Oct.
Khamrui, S., Turley S., Pardon E., Steyaert J., Fan E., Verlinde C. L. M. J., Bergman L. W., and Hol W. G. J., "The structure of the D3 domain of Plasmodium falciparum myosin tail interacting protein MTIP in complex with a nanobody.", Mol Biochem Parasitol, vol. 190, issue 2, pp. 87-91, 2013 Aug.
Ward, A. B., Szewczyk P., Grimard V., Lee C-W., Martinez L., Doshi R., Caya A., Villaluz M., Pardon E., Cregger C., et al., "Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain.", Proc Natl Acad Sci U S A, vol. 110, issue 33, pp. 13386-91, 2013 Aug 13.
2011
Domanska, K., Vanderhaegen S., Srinivasan V., Pardon E., Dupeux F., Marquez J. A., Giorgetti S., Stoppini M., Wyns L., Bellotti V., et al., "Atomic structure of a nanobody-trapped domain-swapped dimer of an amyloidogenic beta2-microglobulin variant.", Proc Natl Acad Sci U S A, vol. 108, issue 4, pp. 1314-9, 2011 Jan 25.
Abskharon, R. N. N., Soror S. H., Pardon E., Hassan H. El, Legname G., Steyaert J., and Wohlkonig A., "Combining in-situ proteolysis and microseed matrix screening to promote crystallization of PrPc-nanobody complexes.", Protein Eng Des Sel, vol. 24, issue 9, pp. 737-41, 2011 Sep.
Oyen, D., Srinivasan V., Steyaert J., and Barlow J. N., "Constraining enzyme conformational change by an antibody leads to hyperbolic inhibition.", J Mol Biol, vol. 407, issue 1, pp. 138-48, 2011 Mar 18.
Rasmussen, S. G. F., Devree B. T., Zou Y., Kruse A. C., Chung K. Young, Kobilka T. Sun, Thian F. Sun, Chae P. Seok, Pardon E., Calinski D., et al., "Crystal structure of the β2 adrenergic receptor-Gs protein complex.", Nature, vol. 477, issue 7366, pp. 549-55, 2011 Sep 29.
Vercruysse, T., Pawar S., De Borggraeve W., Pardon E., Pavlakis G. N., Pannecouque C., Steyaert J., Balzarini J., and Daelemans D., "Measuring cooperative Rev protein-protein interactions on Rev responsive RNA by fluorescence resonance energy transfer.", RNA Biol, vol. 8, issue 2, pp. 316-24, 2011 Mar-Apr.
Steyaert, J., and Kobilka B. K., "Nanobody stabilization of G protein-coupled receptor conformational states.", Curr Opin Struct Biol, vol. 21, issue 4, pp. 567-72, 2011 Aug.
Korotkov, K. V., Johnson T. L., Jobling M. G., Pruneda J., Pardon E., Héroux A., Turley S., Steyaert J., Holmes R. K., Sandkvist M., et al., "Structural and functional studies on the interaction of GspC and GspD in the type II secretion system.", PLoS Pathog, vol. 7, issue 9, pp. e1002228, 2011 Sep.
Westfield, G. H., Rasmussen S. G. F., Su M., Dutta S., Devree B. T., Chung K. Young, Calinski D., Velez-Ruiz G., Oleskie A. N., Pardon E., et al., "Structural flexibility of the G alpha s alpha-helical domain in the beta2-adrenoceptor Gs complex.", Proc Natl Acad Sci U S A, vol. 108, issue 38, pp. 16086-91, 2011 Sep 20.

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